Publications

Peer reviewed journal publications & conference contributions

  • Sadeghi, A., Toropainen, E., Valtari, A., Puranen, J., Ruponen, M., Ranta, V. P., & Urtti, A. (2019). Intravitreal kinetics of macromolecules in rats and rabbits: evaluation with ocular fluorophotometry. Acta Ophthalmologica, 97.
  • Shakirova, J. R., Sadeghi, A., Koblova, A. A., Chelushkin, P. S., Toropainen, E., Tavakoli, S., … & Urtti, A. (2020). Design and synthesis of lipid-mimetic cationic iridium complexes and their liposomal formulation for in vitro and in vivo application in luminescent bioimaging. RSC Advances, 10(24), 14431-14440.
  • Bhattacharya, M., Sadeghi, A., Sarkhel, S., Hagström, M., Bahrpeyma, S., Toropainen, E., … & Urtti, A. (2020). Release of functional dexamethasone by intracellular enzymes: A modular peptide-based strategy for ocular drug delivery. Journal of Controlled Release

 

  • Hammid, A., Vellonen, K. S., Ruponen, M., Urtti, A., & Honkakoski, P. (2019). Characterization and tissue localization of ocular carboxylesterases in multiple species. Acta Ophthalmologica, 97.

 

 

  • Merve Sen, Stefano Salmaso, Paolo Caliceti, MD Al Amin, Eva Kickova, Blanca Arango-Gonzalez, Marius Ueffing. Self-assembling system for a VCP Inhibitor delivers enhanced photoreceptor protection in RhP23Hretinal explants. ProRetina Annual Meeting, Potsdam, Germany, April 3/4, 2020.

 

  • Merve Sen, Stefano Salmaso, Paolo Caliceti, MD Al Amin, Blanca Arango-Gonzalez, Marius Ueffing. Microencapsulation of a small molecule VCP Inhibitor delivers enhanced photoreceptor protection in RhP23H retinal explants. ARVO Annual Meeting 2020, Baltimore, USA, May 1-7, 2020.

 

  • Merve Sen, Oksana Kutsyr, Sylvia Bolz, Mohamed Ali Jarboui, Tsui-Fen Chou, Ray Deshaies, Blanca Arango-Gonzalez, Marius Ueffing. Pharmacological modulation in the VCP/ERAD/proteasome axis rescues photoreceptor degeneration in RhP23H. EVER Conference, Nice, France, September 15-18, 2019.

 

  • Merve Sen, Oksana Kutsyr, Sylvia Bolz, Mohamed Ali Jarboui, Tsui-Fen Chou, Ray Deshaies, Blanca Arango-Gonzalez, Marius Ueffing. Pharmacological interference in the VCP/ERAD/proteasome axis rescues photoreceptor degeneration in RhP23H. Ueffing Lab Retreat, Obermarchtal, Germany, 6-7 June 2019.

 

  • Merve Sen, Oksana Kutsyr, Sylvia Bolz, Mohamed Ali Jarboui, Tsui-Fen Chou, Ray Deshaies, Blanca Arango-Gonzalez, Marius Ueffing. Pharmacological modulation of the VCP/ERAD/proteasome rescues photoreceptor degeneration caused by a dominant rhodopsin mutation. ProRetina Annual Meeting, Potsdam, Germany, March 22/23, 2019.

 

  • Merve Sen, Oksana Kutsyr, Sylvia Bolz, Mohamed Ali Jarboui, Tsui-Fen Chou, Ray Deshaies, Blanca Arango-Gonzalez, Marius Ueffing. Pharmacological interference in the VCP/ERAD/proteasome axis rescues photoreceptor degeneration in RhP23H. ARVO Annual Meeting 2019, Vancouver, Canada, Apr 28- May 2. 2019.

 

  • Effects of Sustained Delivery of ER stress modulators in Animal Models of Retinitis Pigmentosa. Sen, Arango-Gonzalez, Ueffing., PRO RETINA Research Colloquium 2018

 

  • Effects of Sustained Delivery of ER stress modulators in Animal Models of Retinitis Pigmentosa. Sen, Arango-Gonzalez, Ueffing .2017, 15th European Symposium On Controlled Drug Delivery

 

  • Effects of Sustained Delivery of VCP inhibitors in Animal Models of Retinitis Pigmentosa. Sen, Arango-Gonzalez, Ueffing.2017, The Young Researcher Vision Camp

 

  • Impact of in vitro pharmacological inhibition of p97/VCP on the survival of photoreceptor cells in Retinitis Pigmentosa. Arango-Gonzalez, Sen, Chou, Deshaies, Ueffing. 2017, PRO RETINA Research Colloquium 2017

 

  • Effects of Sustained Delivery of ER stress modulators in Animal Models of Retinitis Pigmentosa. Sen, Arango-Gonzalez, Ueffing. 2017, Nena Conference

 

  • Effects of Sustained Delivery of ER stress modulators in Animal Models of Retinitis Pigmentosa. Sen, Arango-Gonzalez, Ueffing.2017, New Horizons in Vision and Hearing Research Conference

 

  • Jaakko Itkonen (Corresponding Author), Ada Annala, Shirin Tavakoli, Blanca Arango-Gonzalez, Marius Ueffing, Elisa Toropainen, Marika Ruponen, Marco G. Casteleijn, Arto Urtti (Corresponding Author). Characterization, Stability, and in Vivo Efficacy Studies of Recombinant Human CNTF and Its Permeation into the Neural Retina in ex Vivo Organotypic Retinal Explant Culture Models. Pharmaceutics 2020, 12, 611; doi:10.3390/pharmaceutics12070611

 

  • Liu, J., Tang, M., Harkin, K., Du, X., Luo, C., Chen, M. and Xu, H., 2020. Single‐cell RNA sequencing study of retinal immune regulators identified CD47 and CD59a expression in photoreceptors—Implications in subretinal immune regulation. Journal of Neuroscience Research, 98(7), pp.1498-1513.

 

  • Sun, D., Tang, M., Zhang, L., Falzon, B.G., Padmanaban, D.B., Mariotti, D., Maguire, P., Xu, H., Chen, M. and Sun, D., 2019. Microplasma assisted synthesis of gold nanoparticle/graphene oxide nanocomposites and their potential application in SERS sensing. Nanotechnology, 30(45), p.455603.

 

  • Chen, M. et al. Cytokine Signaling Protein 3 Deficiency in Myeloid Cells Promotes Retinal Degeneration and Angiogenesis through Arginase-1 Up-Regulation in Experimental Autoimmune Uveoretinitis. Am. J. Pathol. 188, 1007–1020 (2018).
  • Chen M, Zhao J, Ali IHA, Marry S, Augustine J, Bhuckory M, et al. Cytokine Signaling Protein 3 Deficiency in Myeloid Cells Promotes Retinal Degeneration and Angiogenesis through Arginase-1 Up-Regulation in Experimental Autoimmune Uveoretinitis. Am J Pathol. 2018; 88(4):1007–20.

 

  • Macrophage-to-Myofibroblast Transition contributes to subretinal fibrosis secondary to neovascular Age-Related Macular Degeneration Karis Little, PhD; Maria Llorián-Salvador, PhD; Miao Tang; Xuan Du, PhD; Stephen Marry; Mei Chen; Heping Xu Journal of Neuroinflammation 2020

 

  • Versatile Reversible Cross-Linking Strategy to Stabilize CCMV Virus Like Particles for Efficient siRNA Delivery, Chiara Pretto and Jan C. M. van Hest, Bioconjugate Chemistry 2019 30 (12), 3069-3077, DOI: 10.1021/acs.bioconjchem.9b00731

 

 

 

  • Dexamethasone Loaded Liposomes by Thin-Film Hydration and Microfluidic Procedures: Formulation Challenges (Int J Mol Sci. 2020 Mar; 21(5): doi: 3390/ijms21051611).

 

  • Advances in Drug Delivery and Biomaterials: Facts and Vision, page 36, (DOI: 3390/pharmaceutics1101004)
  • Agnès Brun, et.al. In vivo phenotypic and molecular characterization of 
    retinal degeneration in mouse models of three ciliopathies, 
    Experimental Eye Research, Volume 186, September 2019, 107721
  • Ilochonwu, B. C.; Urtti, A.; Hennink, W. E.; Vermonden, T., Intravitreal hydrogels for sustained release of therapeutic proteins. Journal of Controlled Release 2020, 326, 419-441.

 

 

  • Rousou C. et al., A technical protocol for an experimental ex vivo model using arterially perfused porcine eyes, Exp Eye Res., 2019 Apr;181:171-177. doi: 10.1016/j.exer.2019.02.003

 

  • “Magnetofection technology: magnetic-nanoparticles based transfection method for gene therapy”, Advanced in nanotechnology. Nova science publishers. 2020, Marco bassetto, Florent Poulhes, Cedric Sapet, Elise Bonvin, Melanie le Clench and Olivier Zelphati.

 

  • “Synthesis and application of MNPs for the delivery of small organic molecules to the retina “, Marco Bassetto, Daniel Ajoy Moreno, Florent Poulhes, Vincent Marion, Acta Ophthalmologica 97/S263

 

  • Modulation of three key innate immune pathways for the most common retinal degenerative diseases, Isha Akhtar‐Schäfer, Luping Wang, Tim U Krohne, Heping Xu, Thomas Langmann, EMBO Molecular Medicine, 2018, https://doi.org/10.15252/emmm.201708259, John Wiley & Sons Ltd.

 

  • Advances in Drug Delivery and Biomaterials: Facts and Vision, Paolo Caliceti, Pietro Matricardi, Pharmaceutics, 2019, http://www.mdpi.com/1999-4923/11/1/48/pdf, Multidisciplinary Digital Publishing Institute (MDPI)

 

  • Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol,Betaxolol, and Atenolol in Rabbits,Anam Fayyaz,*,†,‡Veli-Pekka Ranta,‡Elisa Toropainen,‡Kati-Sisko Vellonen,‡Giuseppe D’Amico Ricci,§,∥Mika Reinisalo,‡,⊥Emma M. Heikkinen,‡Iain Gardner,†Arto Urtti,‡Masoud Jamei,†and Eva M. del Amo, Mol. Pharmaceutics 2020, 17, 588−594