ESR15: Development of a physiologically based systems pharmacology model of the eye; Simcyp (UK)

SIMCYP is a research based company with expertise in developing Physiologically Based Pharmacokinetic software (PBPK) that is used by academic, regulatory and industrial scientists across the world. The successful applicant will have the opportunity to interact with our team of internationally recognised scientists, specialising in the field of modeling & simulation. The successful applicant will be based at the Simcyp offices in Sheffield, UK but will be registered for a PhD at the University of Eastern Finland.

SIMCYP invites applications for the OCUTHER - European Training Network within Marie Sklodowska Curie Programme. The applications are invited for a:

DOCTORAL STUDENT POSITION (Early Stage Researcher 15: Development of a physiologically based systems pharmacology of the eye)

Drug delivery to the retina is problematic, since only repeated and invasive intravitreal injections are effective means to deliver drug into the retina. In this ESR project, a physiologically based systems pharmacology model of the eye will be developed. The project will involve collation of available information on the relevant physiology, drug metabolizing enzyme and transporter abundance in the healthy and diseased eye and incorporation of the collated information in to a systems pharmacology model capable of predicting drug disposition in the eye. The systems pharmacology model of the eye will be linked to full body PBPK models. In addition, strategies will be developed to allow in vitro-in vivo extrapolation of drug metabolism, transport and permeability processes in the eye.

Required background: BSc or MSc degree in an appropriate field of science (e.g. pharmacy, medicine, chemistry, biology).

What we have to offer

* Employment: 1,0 fte;

* Duration of the contract: 3 years;

* The Marie Sklodowska-Curie Early Stage Researcher living allowance is fixed at €44,895.96 per annum plus allowances. This figure is before employer’s and employee’s deductions for national insurance and taxes per year, which will be paid in Sterling using an appropriate conversion rate.

* Discretionary bonus, pension contribution, health scheme, etc.

What we expect from you

At the time of recruitment you must be in the first four years of your research career and have not yet been awarded a doctoral degree. You must have excellent communication skills and be able to work efficiently in a team. Recruitment is open to all nationalities, but because of mobility rules defined by the EU, at the time of recruitment, candidates must not have resided or carried out their main activity (work, studies, etc.) in the UK for more than 12 months in the three years immediately prior to the reference date (compulsory national service and/or short stays, such as holidays, are not taken into account).

Would you like to know more? * Further information on: The OCUTHER project;

* For more information about this vacancy and the project, please contact:

o Masoud Jamei; o E-mail:

Are you interested?

Your application should include (and be limited to) the following attachments:

* Letter of motivation.

* Curriculum Vitae.

* Brief statement on how you will contribute to this project.

Please submit your application, together with the required attachments, to The deadline for applications is February 5, 2017.