ESR4: Effects of sustained delivery of VCP inhibitors in animal models of retinitis pigmentosa (Germany)

The Institute for Ophthalmic Research at the Eberhard-Karls-Universität Tübingen (EKUT) is headed by Prof. Marius Ueffing and cooperates closely with the University Eye Hospital (Prof. Karl Ulrich Bartz-Schmidt) under the common roof of the Centre for Ophthalmology. Our group focuses on identify pathomechanisms of Retina Degeneration (RD), find genetic and biomarker signatures and develop personalized therapeutic approaches for RD. This last goal includes validation of therapies in animal models and translation into clinical practice.

DOCTORAL STUDENT POSITION (Early Stage Researcher 4: Effects of sustained delivery of VCP inhibitors in animal models of retinitis pigmentosa)

We invite applications for a three-year Early Stage Researcher (Ph.D. student) position being part of OCUTHER - European Training Network within Marie Sklodowska Curie Programme. Applicants should be self-motivated and able of analytical thinking. 
A strong interest and background in neurosciences, cell biology, cell signalling or molecular biology is favourable. Proficient communication skills in English as well as organizational skills 
are required.

The young researcher will gain knowledge in retina structure as well as in cell biology, and will develop various in vivo and in vitro skills essential for validate neuroprotective therapeutic approaches in retina degeneration. The Early Stage Researcher (ESR) will be involved in research of sustained pharmacological manipulation of protein homeostasis on the survival of photoreceptor cells in animal models of retinitis pigmentosa. To this end, the ESR will participate in the design, generation and testing of a sustained drug delivery system for small molecule compounds and validates them in animal models of autosomal dominant retinitis pigmentosa in vitro as well as in vivo. Moreover the ESR will investigate the relationship between proteins involved in protein homeostasis mediated by Endoplasmic-Reticulum-Associated Protein Degradation (ERAD) and processes of photoreceptor cell death.

BENEFITS

Highly competitive salary as well as funds to participate in training activities of the OcuTher network as well as in international conferences. The candidate will also enrol in the PhD program of the Graduate Training Center of Neuroscience at Eberhard Karls University Tübingen (http://www.neuroschool-tuebingen.de) for lectures, seminars, and other learning activities.

Please send CV and a letter of intent to Blanca Arango-Gonzalez (blanca.arango-gonzalez@klinikum.uni-uni-tuebingen.de)

Further information on the OcuTher Initial Training Network can be found at [OcuTher website]

EU RESEARCH FRAMEWORK PROGRAMME

H2020 – Marie Sklodowska Curie Actions

JOB DETAILS

TYPE OF CONTRACT: Temporary (3 years)

STATUS: Full-time

Hours per week: 38.5h (100%)

ORGANISATION / INSTITUTE CONTACT DATA

Dr. Blanca Arango-Gonzalez

University Hospital Tübingen, Germany

Centre for Ophthalmology

Institute for Ophthalmic Research

Head: Prof. Dr. Marius Ueffing

Elfriede-Aulhorn-Str. 7

D-72076 Tuebingen, Germany

Tel: +49 (0) 7071 2980741

Fax: +49 (0) +49 (0) 7071295777

E-mail: blanca.arango-gonzalez@klinikum.uni-tuebingen.de

WEBSITE: http://www.eye-tuebingen.de/ueffinglab/

APPLICATION DETAILS

ENVISAGED JOB STARTING DATE: Spring 2017, negotiable

APPLICATION DEADLINE: Feb 5th, 2017

HOW TO APPLY: by e-mail to blanca.arango-gonzalez@klinikum.uni-tuebingen.de

Your application should include (and be limited to) the following attachments:

  • Letter of motivation
  • Curriculum Vitae
  • Brief statement on how you will contribute to this project

REQUIRED EDUCATION LEVEL

DEGREE: Master degree or equivalent

DEGREE FIELD: medical sciences, biological sciences, or similar with an emphasis on neurosciences,

REQUIRED LANGUAGES

LANGUAGE: English

LANGUAGES LEVEL (good)

REQUIRED RESEARCH EXPERIENCE

MAIN RESEARCH FIELD: medical sciences, biological sciences

RESEARCH SUB FIELD: neuroscience or related

YEARS OF RESEARCH EXPERIENCE: at least 2 years

COMMENT

Candidates must not have resided or carried out their main activity in Germany for more than 12 months in the 3 years immediately prior to their recruitment date. The candidate should not possess a doctoral degree and should have less than 4 years of research experience after graduation with a degree allowing to start a Ph.D. thesis.

REQUIRED SKILLS

SKILLS: We are searching for an Early Stage Researcher who is interested (and should have some experience) in neurosciences. Broad knowledge of the visual system or pre‐existing laboratory experience would be of advantage.